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xEO Mega®

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Primary Benefits

• Promotes cardiovascular health by reducing oxidative stress and mediating healthy cellular response to inflammatory markers*

• Supports healthy joint function and comfort*

• Provides important modulating nutrients for healthy immune function*

• Protects against lipid oxidation and supports healthy function of the brain*

• Promotes healthy skin*

• Delivers 1,000 mg of pure, concentrated, molecularly-filtered fish oil with 340 mg of EPA and 240 mg of DHA per daily serving

• Provides a wide range of essential fatty acids including EPA, DHA, GLA, and CLA from

marine and plant sources to help maintain a healthy balance of omega fatty acids

• Includes a clinically-substantiated microalgae carotenoid extract of pure astaxanthin

• Formulated with a proprietary blend of dōTERRA CPTG Certified Pure Therapeutic

Grade® essential oils of Clove, Frankincense, Thyme, Cumin, Wild Orange, Peppermint,

Ginger, Caraway, and German Chamomile

• Includes 800 IU of natural vitamin D and 60 IU of natural vitamin E

• Presented in a clinically-substantiated nanosomal lipid assimilation system that enhances lipid biovailability in the digestive tract

• Does not contain milk or wheat products

• Specially formulated to be used daily with Alpha CRS+ and Microplex VMz as a

comprehensive dietary supplement foundation for a lifetime of vitality and wellness*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

**Sunlight and other light sources can oxidize the astaxanthin if not stored in a dark, cool, dry environment.

dōTERRA xEO Mega® Essential Oil Omega Complex is a unique formula of CPTG Certified Pure Therapeutic Grade® essential oils and a proprietary blend of marine- and land-sourced omega fatty acids. Omega fatty acids help support healthy joint, cardiovascular, and brain health; help support healthy immune function; and have been shown to help mediate a healthy inflammatory response in cells.* A single daily dose of xEO Mega provides 1,000 milligrams of marine lipids with 340 mg of EPA and 240 mg of DHA and a blend of plant-sourced essential fatty acids. xEO Mega also includes 800 IU of natural vitamin D, 60 IU of natural vitamin E, and 1 mg of pure astaxanthin, a powerful antioxidant carotenoid harvested from microalgae. The bioavailability of the xEO Mega formula is enhanced through a nanosomal lipid assimilation system and is encapsulated in a vegetarian-friendly softgel.



Essential Fatty Acids (EFAs) are nutrients required for many key functions in the human body including cell growth, brain development, muscle activity, immune function, joint health, and many others. While some fatty acids can be produced inside the body, “essential” fatty acids cannot be produced by our bodies; therefore, we rely upon the food we eat to supply us with these important nutrients. The most common of the essential fatty acids are omega-6 and omega-3 fatty acids. Modern science suggests that for optimal health, humans should consume a one-to-one ratio of omega-6 to omega-3 essential fatty acids in the foods they eat. Unfortunately, due to the abundance of omega-6 fatty acids in vegetable oils and our increasing consumption of fried and fatty foods, a typical western diet includes omega-6 fatty acids in a ratio as high as 15 to one. While our diets must include some omega-6 fatty acids as essential nutrients for life, the disproportionate consumption of omega-6 fatty acids in their unhealthy hydrogenated or trans fat forms has been linked to diseases including cardiovascular disease, cancer, osteoporosis, and inflammatory and autoimmune diseases.  Studies also link low intake of omega-3 fatty acids to a higher prevalence of depression and other mental illnesses.


Conversely, there is an enormous body of scientific evidence supporting the health benefits of increasing the dietary intake of omega-3 fatty acids. Studies have shown that increasing omega-3 fatty acid consumption has a positive effect on cardiovascular health and brain function, and helps balance cellular inflammatory response.


Increased consumption of omega-3 fatty acids has also been shown to have a positive impact on joint health and mobility and skin health.* Restoring the balance of omega-3 and omega-6 fatty acids is an important step in keeping your body healthy. This can be done by decreasing your intake of unhealthy foods high in omega-6 fatty acids and increasing your intake of foods that are rich in omega-3 fatty acids. Fish is an excellent source of dietary omega-3 fatty acids, but omega-3s can also be found in olive oil and

the oils of some nuts and seeds. Because of growing anxiety over the levels of toxins and

heavy metals present in many of the world’s oceans, daily fish consumption as a source of omega-3 fatty acids is not acceptable to some consumers. In fact, many nutritional experts warn against frequent fish consumption to prevent exposure to these toxic pollutants. One daily dose of xEO Mega provides 1,000 milligrams of pure, micro-filtered marine lipids with 340 mg of EPA and 240 mg of DHA omega-3 essential fatty acids.

Another convenient source of healthy essential fatty acids can be found in flaxseed oil. Flaxseed oil provides an omega-3 fatty acid known as alpha-linolenic acid (ALA). While DHA and EPA are readily available to the body when consumed from fish, ALA can also be synthesized to DHA and EPA in the human body. dōTERRA xEO Mega contains a proprietary plant-based essential fatty acid blend of flaxseed oil, borage seed oil, cranberry seed oil, and pomegranate seed oil (containing CLA) to help maintain the

appropriate balance of essential fatty acids.


CPTG Certified Pure Therapeutic Grade® Essential Oils

xEO Mega also contains a proprietary blend of dōTERRA CPTG Certified Pure Therapeutic Grade essential oils that work in harmony with the essential fatty acids in xEO Mega. Clove oil and the constituent thymol in Thyme oil are powerful antioxidants that work to enhance the overall efficacy of xEO Mega by adding protective powers against oxidation. The essential oil blend also supports healthy cellular inflammatory response and immune function and has digestive calming effects which make taking xEO Mega as pleasant as it is healthful. The essential oils in xEO Mega also function as a natural preservative system that protects essential fatty acids and lipidsoluble vitamins from oxidizing and going rancid. Astaxanthin and Vitamin E Omega-3 fatty acids are important for circulatory and brain health. The brain is made up of essential lipids that, as with the free lipids traveling in the circulatory system, are prone to degradation through free-radical oxidation. xEO Mega includes the powerful antioxidant caratenoid astaxanthin that helps protect against lipid oxidation in the brain and throughout the circulatory system. Astaxanthin has been clinically-substantiated to provide powerful antioxidant and circulatory benefits, support eye health, improve muscle strength and endurance, aid the liver and digestive system, support skin health, and modulate healthy immune function.* The astaxanthin used in xEO Mega is a standardized extract of microalgae cultivated in a pure water system and activated by sunlight*.* In response to exposure to UV rays, the microalgae produces astaxanthin as a defense mechanism against oxidation. The microalgae changes from a light green to a deep crimson red, the astaxanthin is then extracted from the microalgae, microfiltered, and standardized for potency. The astaxanthin is coupled with natural vitamin E to provide additional circulatory and systemic benefits as powerful antioxidant additions to the antioxidant essential oils in xEO Mega.


Vitamin D

xEO Mega also includes 800 IU of natural vitamin D. Vitamin D is a fat-soluble vitamin

present in a limited number of foods such as fish, beef liver, cheese, egg yolks, and fortified dairy products. It can also be synthesized in the body when triggered by exposure to sunlight. Vitamin D plays an essential role in bone health and growth. As with the essential fatty acids in xEO Mega, vitamin D also plays an important role in modulating immune function and inflammatory response on a cellular level.


Nanosomal Lipid Assimilation System™

When fat-soluble nutrients are consumed in the foods we eat, they remain fairly unchanged in the stomach environment and must undergo an emulsification process to pass the protective aqueous barrier of the intestinal tract. xEO Mega employs a revolutionary new lipid delivery system that enhance the bioavailability of its unique blend of essential fatty acids, essential oils, and lipid-soluble vitamins through a nanoemulsification process that separates and surrounds each nutrient with a natural

surfactant, encapsulating them into small spheres called micelles. These very small

micelles readily pass through the aqueous barrier of the digestive tract and traveling

directly to specialized digestive cells and on to the lymphatic system for transport throughout the body. This proprietary nanosomal delivery system has been clinically-demonstrated to support increased bioavailability of specific lipid-soluble nutrients.


xEO Mega Essential Oil Omega Complex

xEO Mega is a revolutionary approach to supplementing our diets with essential fatty acids and other fat soluble nutrients that help support circulatory health, brain health,  healthy inflammatory response, and optimal immune function among many other systemic benefits. This unique formula of lipid-soluble nutrients is packaged in small, vegetarian-friendly softgels. xEO Mega® is formulated to be used daily with dōTERRA Alpha CRS+® and Microplex VMz™ as a comprehensive dietary supplement foundation

for a lifetime of vitality and wellness.



Adults, take 4 to 8 softgels per day with food. xEO Mega is formulated to be used daily with Alpha CRS+ and Microplex VMz. All three products can be found in one convenient

pack—Lifelong Vitality pack or Vegan Lifelong Vitality pack. Save $69 by buying them in the pack.



Q: Does xEO Mega need to be refrigerated?

A: xEO Mega is designed to be stable at room  temperature throughout its shelf life. However, refrigeration is recommended to extend its shelf life or to maximize the potency of the fragile omega-3 fatty acids.


Q: Does xEO Mega need to be taken with food?

A: xEO Mega should always be taken immediately before or right at the beginning of a full meal.


Q: Is there a vegan version of xEO Mega (no fish)?

A: vEO Mega is available for those that do not wish to consume any animal-sourced ingredients.


Q: Can my kids take xEO Mega instead of the IQ Mega?

A: xEO Mega is safe for children and teenagers at a half dose. However, IQ Mega provides a higher dose of essential omega-3 fatty acids, which are critically important for the development years.


Q: If I take the IQ Mega, do I need to take xEO Mega too?

A: No, one or the other should be chosen.


Q: What fish is utilized in the Marine Omega Blend and what is the country of origin?

A: Though the fishing ground may vary, the Marine Omega blend comes primarily from

anchovy and mackerel from the waters off the coast of Peru.


Q: Why do I needthe Marine and Land Omega Blends?

A: They provide essential omega-3 fatty acids that cannot be made by the body and must

be obtained from the diet. Normal fish and other oil consumption does not meet the needs of most people. Omega-3 fatty acids are required for a number of needs in the

body, including anti-inflammatory reactions.


Q: What Does xEO Mega mean?

A: EO stands for essential oil, as this product also contains a powerful essential oil blend

for internal use. Mega refers to Omega-3 fatty acids. The x reflects improvements that

have been made to the product since it was first launched as EO Mega.



• Microplex VMz

• Alpha CRS+

• TerraZyme



Huang YM, Yan SF, Ma L, et al.

Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration.

Nutrition. 2013;29:387-392.


Pan A, Chen M, Chowdhury R, et al.

α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis.

The American Journal of Clinical Nutrition. 2012;96:1262-1273.


Tasset-Cuevas I, Fernandez-Bedmar Z, Lozano-Baena MD, et al.

Protective effect of borage seed oil and gamma linolenic acid on DNA: In Vivo and In Vitro


PLoS ONE. 2013; 8(2): e56986.


Minihane AM.

Fish oil omega-3 fatty acids and cardio-metabolic health, alone or with statins.

European Journal of Clinical Nutrition. 2013;67:536-540.


Song C.

Essential fatty acids as potential antiinflammatory agents in the treatment of affective disorders.

Mod Trends Pharmacopsychiatry. 2013;28:75-89.